Left-arm spinner Steve O'Keefe's career-best six-wicket haul and skipper Steve Smith's half century helped Australia take a commanding lead of 298 runs over India at stumps on the second day of the opening cricket Test here on Friday.

Earlier, the visitors -- ending their first innings at 260 -- skittled out the hosts for a paltry 105. In their second essay, Australia were 143 for four when end of play was called.

In the Australian second innings, Smith, who was dropped thrice on 23, 29 and 37, was unbeaten on 59 with all-rounder Mitchell Marsh giving him company on 21.